smallpox

noun

small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: an acute contagious febrile disease of humans that is caused by a poxvirus (species Variola virus of the genus Orthopoxvirus), is characterized by a skin eruption with pustules, sloughing, and scar formation, and is believed to have been eradicated globally by widespread vaccination

called also variola

Examples of smallpox in a Sentence

Recent Examples on the Web
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The program has a long, rich history since its establishment in 1951, which includes contributing to the eradication of smallpox, among other achievements. Ars Technica, 14 Feb. 2025 The agency also regularly inspects the smallpox labs for safety lapses. William J. Broad, New York Times, 12 Feb. 2025 Hauksbee wrote that he himself had been inspired by the methods of English physician James Jurin, who in the 1720s published outcomes of inoculating people against smallpox, a precursor to smallpox vaccination. Ashley Strickland, CNN, 18 Jan. 2025 The impact of specific vaccines has been remarkable: The smallpox vaccine led to the complete eradication of the disease, declared by the World Health Organization in 1980. A.j. Russo, Baltimore Sun, 13 Jan. 2025 See All Example Sentences for smallpox

Word History

First Known Use

circa 1562, in the meaning defined above

Time Traveler
The first known use of smallpox was circa 1562

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Cite this Entry

“Smallpox.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/smallpox. Accessed 13 Mar. 2025.

Kids Definition

smallpox

noun
small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: a sometimes deadly disease that is caused by a virus, is characterized by fever and a skin rash, and is believed to have been wiped out worldwide as a result of vaccination

Medical Definition

smallpox

noun
small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: an acute contagious febrile disease of humans that is caused by a poxvirus of the genus Orthopoxvirus (species Variola virus), is characterized by skin eruption with pustules, sloughing, and scar formation, and is believed to have been eradicated globally by widespread vaccination

called also variola

see variola major, variola minor

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