antihistamine

noun

an·​ti·​his·​ta·​mine ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio)
-mən,
ˌan-tī-
: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms
antihistamine adjective
antihistaminic adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Your healthcare provider will explain when to use an antihistamine versus an EpiPen.2 3. Wendy Wisner, Health, 17 Apr. 2025 Decades later, when over-the-counter antihistamines like Benadryl became popular, some parents began using them, off-label, as a sleep aid. ArsTechnica, 8 Apr. 2025 Oral antihistamines, for example, can help relieve sneezing, itching, a stuffy or runny nose, and watery eyes. Nora Colomer, FOXNews.com, 5 Apr. 2025 There are two main categories of OTC drugs often touted by allergists for alleviating allergy symptoms: oral antihistamines and nasal corticosteroids. Erica Sloan, SELF, 2 Apr. 2025 See All Example Sentences for antihistamine

Word History

First Known Use

1946, in the meaning defined above

Time Traveler
The first known use of antihistamine was in 1946

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Cite this Entry

“Antihistamine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antihistamine. Accessed 23 Apr. 2025.

Kids Definition

antihistamine

noun
an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn How to pronounce antihistamine (audio)
-mən,
ˌan-ˌtī-
: any of various drugs used for treating allergic reactions and cold symptoms

Medical Definition

antihistamine

1 of 2 adjective
an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio)
: tending to block or counteract the physiological action of histamine
human blood lacks antihistamine activity

antihistamine

2 of 2 noun
: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

More from Merriam-Webster on antihistamine

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