: a semisynthetic illicit organic compound C20H25N3O derived from ergot that induces extreme sensory distortions, altered perceptions of reality, and intense emotional states, that may also produce delusions or paranoia, and that may sometimes cause panic reactions in response to the effects experienced

called also lysergic acid diethylamide

Examples of LSD in a Sentence

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People who dislike Phish do so with equal fervor, often while making jokes about the degenerative effects of LSD on the prefrontal cortex. Amanda Petrusich, New Yorker, 14 Apr. 2025 In this perp’s youth, a seemingly nascent case of schizophrenia was exacerbated by habitual LSD use and the yellow nattering Thronglets, which convinced him that their chirping contains a cryptic, apocalyptic message. Charles Bramesco, Vulture, 10 Apr. 2025 And unsurprisingly, mild psychedelic effects were reported by several participants in the LSD group. New Atlas, 3 Apr. 2025 Handler also addressed taking LSD during her recent 50th birthday celebrations in February. Becca Longmire, People.com, 28 Mar. 2025 See All Example Sentences for LSD

Word History

Etymology

borrowed from German, from Lysergsäure-Diäthylamid "lysergic acid diethylamide"

First Known Use

1950, in the meaning defined above

Time Traveler
The first known use of LSD was in 1950

Browse Nearby Words

Cite this Entry

“LSD.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/LSD. Accessed 24 Apr. 2025.

Kids Definition

: an illegal drug that causes abnormal sensations, extreme and changeable states of emotion, unnatural changes in the way time and space are experienced, and hallucinations and that may sometimes cause panic in response to the effects experienced

Medical Definition

: a semisynthetic illicit organic compound C20H25N3O derived from ergot that induces extreme sensory distortions, altered perceptions of reality, and intense emotional states, that may also produce delusions or paranoia, and that may sometimes cause panic reactions in response to the effects experienced

called also acid, lysergic acid diethylamide, lysergide

More from Merriam-Webster on LSD

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